Drug interactions
Dronabinol + Nevirapine
Severity: Minor
Dronabinol and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized by CYP2C9 and CYP3A4, so nevirapine may reduce its concentrations and weaken its effect on appetite or nausea. The interaction is predicted from mechanism and has not been well studied.
What this interaction means in plain words
Dronabinol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 (and possibly CYP2C9), increasing dronabinol metabolism.
What to do
Monitor for reduced antiemetic or appetite-stimulating effect and increase the dronabinol dose within labeled limits if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Nevirapine?
MediHelp rates the interaction as minor. Dronabinol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronabinol is metabolized by CYP2C9 and CYP3A4, so nevirapine may reduce its concentrations and weaken its effect on appetite or nausea. The interaction is predicted from mechanism and has not been well studied.
How serious is the interaction between Dronabinol and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or appetite-stimulating effect and increase the dronabinol dose within labeled limits if needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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