Drug interactions
Dronabinol + Rucaparib
Severity: Minor
Dronabinol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and CYP2C9 and may modestly raise dronabinol exposure. Clinically significant effects are uncertain but increased sedation or dizziness is possible.
What this interaction means in plain words
Dronabinol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4 and CYP2C9, slightly reducing dronabinol clearance.
What to do
Monitor for increased cannabinoid effects such as drowsiness and dizziness. Reduce the dronabinol dose only if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Dronabinol with Rucaparib?
MediHelp rates the interaction as minor. Dronabinol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and CYP2C9 and may modestly raise dronabinol exposure. Clinically significant effects are uncertain but increased sedation or dizziness is possible.
How serious is the interaction between Dronabinol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased cannabinoid effects such as drowsiness and dizziness. Reduce the dronabinol dose only if symptoms occur.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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