Drug interactions
Dronedarone + Duloxetine
Severity: Moderate
Dronedarone and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, one of the enzymes metabolizing duloxetine, so duloxetine concentrations may rise. This can increase nausea, dizziness, blood pressure elevation and other dose-related adverse effects.
What this interaction means in plain words
Dronedarone and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Duloxetine belongs to Central Nervous System.
Why it happens
Dronedarone inhibition of CYP2D6 reduces duloxetine metabolism.
What to do
Monitor for duloxetine adverse effects, including blood pressure and serotonergic symptoms. Lower the duloxetine dose if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dronedarone with Duloxetine?
MediHelp rates the interaction as moderate. Dronedarone and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6, one of the enzymes metabolizing duloxetine, so duloxetine concentrations may rise. This can increase nausea, dizziness, blood pressure elevation and other dose-related adverse effects.
How serious is the interaction between Dronedarone and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects, including blood pressure and serotonergic symptoms. Lower the duloxetine dose if tolerability is poor.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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