Drug interactions
Dronedarone + Eletriptan
Severity: Moderate
Dronedarone and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is cleared mainly by CYP3A4, and dronedarone is a moderate inhibitor of this enzyme. Eletriptan levels may increase, raising the risk of vasoconstrictive and other adverse effects.
What this interaction means in plain words
Dronedarone and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by dronedarone decreases eletriptan first-pass and systemic metabolism.
What to do
Use the lowest effective eletriptan dose and avoid repeat dosing within 24 hours. Watch for chest tightness, blood pressure rise and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Dronedarone with Eletriptan?
MediHelp rates the interaction as moderate. Dronedarone and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is cleared mainly by CYP3A4, and dronedarone is a moderate inhibitor of this enzyme. Eletriptan levels may increase, raising the risk of vasoconstrictive and other adverse effects.
How serious is the interaction between Dronedarone and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and avoid repeat dosing within 24 hours. Watch for chest tightness, blood pressure rise and other adverse effects.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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