Drug interactions
Dronedarone + Estradiol
Severity: Minor
Dronedarone and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is partly metabolized by CYP3A4, which dronedarone inhibits. Estrogen exposure may increase modestly, with possible estrogenic adverse effects such as breast tenderness or bleeding changes.
What this interaction means in plain words
Dronedarone and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Estradiol belongs to Endocrine.
Why it happens
Dronedarone inhibition of CYP3A4 and P-glycoprotein modestly reduces estradiol clearance.
What to do
No routine dose change is needed. Review the patient for estrogen-related adverse effects and adjust the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Dronedarone with Estradiol?
MediHelp rates the interaction as minor. Dronedarone and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is partly metabolized by CYP3A4, which dronedarone inhibits. Estrogen exposure may increase modestly, with possible estrogenic adverse effects such as breast tenderness or bleeding changes.
How serious is the interaction between Dronedarone and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Review the patient for estrogen-related adverse effects and adjust the estradiol dose if they occur.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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