Drug interactions
Dronedarone + Fedratinib
Severity: Major
Dronedarone and Fedratinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise dronedarone concentrations, increasing the risk of QT prolongation, bradycardia and heart failure effects. Dronedarone is itself a CYP3A4 substrate and a moderate inhibitor, and fedratinib is also metabolized by CYP3A4, so each drug may affect the other.
What this interaction means in plain words
Dronedarone and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing dronedarone clearance, and dronedarone may reduce fedratinib clearance through CYP3A4 inhibition.
What to do
Avoid if possible; otherwise monitor ECG and heart rate, and consider reducing the fedratinib dose per labeling for CYP3A4 inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Fedratinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Dronedarone 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: substrates of P-glycoproteins, CYP 3A4 or CYP 2D6; "Dronedarone has therefore, the potential to interact on medicinal products substrates of P-glycoproteins, CYP 3A4 or CYP 2D6.") — electronic medicines compendium (UK SmPC)
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dronedarone with Fedratinib?
MediHelp rates the interaction as major. Dronedarone and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib inhibits CYP3A4 and may raise dronedarone concentrations, increasing the risk of QT prolongation, bradycardia and heart failure effects. Dronedarone is itself a CYP3A4 substrate and a moderate inhibitor, and fedratinib is also metabolized by CYP3A4, so each drug may affect the other.
How serious is the interaction between Dronedarone and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and heart rate, and consider reducing the fedratinib dose per labeling for CYP3A4 inhibitors.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
