Drug interactions
Dronedarone + Fexofenadine
Severity: Minor
Dronedarone and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and may increase exposure to fexofenadine, a P-gp substrate. Fexofenadine has a wide safety margin, so the effect is usually of limited clinical significance.
What this interaction means in plain words
Dronedarone and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Fexofenadine belongs to Respiratory.
Why it happens
Inhibition of P-glycoprotein efflux of fexofenadine by dronedarone.
What to do
No routine adjustment is needed. Watch for increased antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Fexofenadine?
MediHelp rates the interaction as minor. Dronedarone and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits P-glycoprotein and may increase exposure to fexofenadine, a P-gp substrate. Fexofenadine has a wide safety margin, so the effect is usually of limited clinical significance.
How serious is the interaction between Dronedarone and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased antihistamine adverse effects.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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