Drug interactions
Dronedarone + Levamlodipine
Severity: Moderate
Dronedarone and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can increase levamlodipine exposure by inhibiting its CYP3A4 metabolism. This may cause more pronounced hypotension and peripheral edema, and dronedarone itself can slow heart rate and conduction.
What this interaction means in plain words
Dronedarone and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Levamlodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone reduces levamlodipine clearance.
What to do
Monitor blood pressure, heart rate and edema when starting or adjusting the combination. Reduce the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Dronedarone with Levamlodipine?
MediHelp rates the interaction as moderate. Dronedarone and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can increase levamlodipine exposure by inhibiting its CYP3A4 metabolism. This may cause more pronounced hypotension and peripheral edema, and dronedarone itself can slow heart rate and conduction.
How serious is the interaction between Dronedarone and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema when starting or adjusting the combination. Reduce the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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