Drug interactions
Dronedarone + Omaveloxolone
Severity: Moderate
Dronedarone and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase omaveloxolone concentrations, raising the risk of adverse effects such as liver enzyme elevations and nausea. Omaveloxolone is mainly a CYP3A4 substrate.
What this interaction means in plain words
Dronedarone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Omaveloxolone belongs to Central Nervous System.
Why it happens
Dronedarone inhibits CYP3A4, reducing omaveloxolone clearance.
What to do
Avoid if possible. If necessary, reduce omaveloxolone to the labeled lower dose and monitor liver tests and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Dronedarone with Omaveloxolone?
MediHelp rates the interaction as moderate. Dronedarone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase omaveloxolone concentrations, raising the risk of adverse effects such as liver enzyme elevations and nausea. Omaveloxolone is mainly a CYP3A4 substrate.
How serious is the interaction between Dronedarone and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, reduce omaveloxolone to the labeled lower dose and monitor liver tests and tolerability.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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