Drug interactions
Dronedarone + Palbociclib
Severity: Moderate
Dronedarone and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is cleared mainly by CYP3A4, and dronedarone is a moderate inhibitor. Higher palbociclib exposure may worsen neutropenia and other adverse effects.
What this interaction means in plain words
Dronedarone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
Dronedarone inhibition of CYP3A4 decreases palbociclib metabolism.
What to do
Monitor neutrophil counts closely and interrupt or reduce the palbociclib dose for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Dronedarone with Palbociclib?
MediHelp rates the interaction as moderate. Dronedarone and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is cleared mainly by CYP3A4, and dronedarone is a moderate inhibitor. Higher palbociclib exposure may worsen neutropenia and other adverse effects.
How serious is the interaction between Dronedarone and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts closely and interrupt or reduce the palbociclib dose for significant neutropenia.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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