Drug interactions
Dronedarone + Paromomycin
Severity: Minor
Dronedarone and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is minimally absorbed orally, so P-glycoprotein inhibition by dronedarone is unlikely to produce meaningful systemic exposure. The interaction is largely theoretical.
What this interaction means in plain words
Dronedarone and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Paromomycin belongs to Anti Bacterial.
Why it happens
Dronedarone inhibits P-glycoprotein, which might slightly increase paromomycin absorption.
What to do
No action is usually needed; monitor renal function if paromomycin is used for prolonged periods or with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Dronedarone with Paromomycin?
MediHelp rates the interaction as minor. Dronedarone and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paromomycin is minimally absorbed orally, so P-glycoprotein inhibition by dronedarone is unlikely to produce meaningful systemic exposure. The interaction is largely theoretical.
How serious is the interaction between Dronedarone and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; monitor renal function if paromomycin is used for prolonged periods or with renal impairment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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