Drug interactions
Dronedarone + Repotrectinib
Severity: Major
Dronedarone and Repotrectinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and P-glycoprotein, which may increase repotrectinib exposure and its adverse effects, such as neurologic toxicity. Repotrectinib is itself a CYP3A inducer and may in turn lower dronedarone levels, making the net effect unpredictable.
What this interaction means in plain words
Dronedarone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Repotrectinib belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4 and P-gp, raising repotrectinib exposure, while repotrectinib induces CYP3A4 and may reduce dronedarone exposure.
What to do
Avoid concomitant use; consider an alternative antiarrhythmic. If unavoidable, monitor closely for repotrectinib toxicity, particularly dizziness, ataxia and other CNS effects, and for loss of dronedarone effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Dronedarone with Repotrectinib?
MediHelp rates the interaction as major. Dronedarone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits CYP3A4 and P-glycoprotein, which may increase repotrectinib exposure and its adverse effects, such as neurologic toxicity. Repotrectinib is itself a CYP3A inducer and may in turn lower dronedarone levels, making the net effect unpredictable.
How serious is the interaction between Dronedarone and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; consider an alternative antiarrhythmic. If unavoidable, monitor closely for repotrectinib toxicity, particularly dizziness, ataxia and other CNS effects, and for loss of dronedarone effect.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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