Drug interactions
Dronedarone + Rucaparib
Severity: Moderate
Dronedarone and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate CYP3A inhibitor and may modestly raise dronedarone exposure. Higher dronedarone levels could increase QT prolongation, bradycardia and gastrointestinal effects.
What this interaction means in plain words
Dronedarone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibition of CYP3A4 reduces dronedarone metabolism.
What to do
Monitor ECG and heart rate and adjust therapy if QT prolongation or bradycardia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Dronedarone with Rucaparib?
MediHelp rates the interaction as moderate. Dronedarone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak-to-moderate CYP3A inhibitor and may modestly raise dronedarone exposure. Higher dronedarone levels could increase QT prolongation, bradycardia and gastrointestinal effects.
How serious is the interaction between Dronedarone and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate and adjust therapy if QT prolongation or bradycardia appears.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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