Drug interactions
Dronedarone + Stiripentol
Severity: Moderate
Dronedarone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and may induce CYP3A4, so dronedarone exposure may be unpredictably altered. Increased levels raise the risk of QT prolongation and bradycardia, while reduced levels may reduce antiarrhythmic efficacy.
What this interaction means in plain words
Dronedarone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol affecting dronedarone metabolism.
What to do
Monitor ECG and heart rate and the clinical response to dronedarone. Consider an alternative antiarrhythmic if the effect is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Dronedarone with Stiripentol?
MediHelp rates the interaction as moderate. Dronedarone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and may induce CYP3A4, so dronedarone exposure may be unpredictably altered. Increased levels raise the risk of QT prolongation and bradycardia, while reduced levels may reduce antiarrhythmic efficacy.
How serious is the interaction between Dronedarone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate and the clinical response to dronedarone. Consider an alternative antiarrhythmic if the effect is unstable.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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