Drug interactions
Dronedarone + Temsirolimus
Severity: Moderate
Dronedarone and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase exposure to temsirolimus and its active metabolite sirolimus. This could increase adverse effects such as mucositis, cytopenias, hyperglycemia and pneumonitis.
What this interaction means in plain words
Dronedarone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by dronedarone decreases temsirolimus and sirolimus metabolism.
What to do
Monitor for temsirolimus toxicity and reduce the dose if adverse effects emerge. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Dronedarone with Temsirolimus?
MediHelp rates the interaction as moderate. Dronedarone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase exposure to temsirolimus and its active metabolite sirolimus. This could increase adverse effects such as mucositis, cytopenias, hyperglycemia and pneumonitis.
How serious is the interaction between Dronedarone and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and reduce the dose if adverse effects emerge. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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