Drug interactions
Dronedarone + Tramadol
Severity: Moderate
Dronedarone and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, which converts tramadol to its active opioid metabolite O-desmethyltramadol. Opioid analgesia may be reduced while parent tramadol concentrations rise, which could increase the serotonergic and seizure-related risk of tramadol.
What this interaction means in plain words
Dronedarone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Tramadol belongs to Musculoskeletal.
Why it happens
Dronedarone inhibition of CYP2D6 reduces tramadol activation to O-desmethyltramadol and increases parent drug exposure.
What to do
Monitor for inadequate analgesia and for signs of serotonergic toxicity or seizures. Consider a non-CYP2D6-dependent analgesic if pain control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Tramadol?
MediHelp rates the interaction as moderate. Dronedarone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6, which converts tramadol to its active opioid metabolite O-desmethyltramadol. Opioid analgesia may be reduced while parent tramadol concentrations rise, which could increase the serotonergic and seizure-related risk of tramadol.
How serious is the interaction between Dronedarone and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for inadequate analgesia and for signs of serotonergic toxicity or seizures. Consider a non-CYP2D6-dependent analgesic if pain control is poor.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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