Drug interactions
Dronedarone + Zonisamide
Severity: Minor
Dronedarone and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolized by CYP3A4, so dronedarone could modestly raise its concentrations. Dose-related effects such as somnolence and dizziness may increase.
What this interaction means in plain words
Dronedarone and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Zonisamide belongs to Central Nervous System.
Why it happens
Dronedarone inhibits CYP3A4-mediated metabolism of zonisamide.
What to do
Monitor for sedation, dizziness and cognitive effects, and adjust the zonisamide dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Dronedarone with Zonisamide?
MediHelp rates the interaction as minor. Dronedarone and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolized by CYP3A4, so dronedarone could modestly raise its concentrations. Dose-related effects such as somnolence and dizziness may increase.
How serious is the interaction between Dronedarone and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and cognitive effects, and adjust the zonisamide dose if they occur.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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