Drug interactions
Drospirenone + Felbamate
Severity: Moderate
Drospirenone and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can induce CYP3A4 and may reduce hormonal contraceptive concentrations, risking contraceptive failure. Reduced efficacy of drospirenone-containing products is therefore possible.
What this interaction means in plain words
Drospirenone and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Felbamate belongs to Central Nervous System.
Why it happens
Felbamate induces CYP3A4, accelerating the metabolism of drospirenone and the estrogen component.
What to do
Use an additional or alternative non-hormonal contraceptive method during felbamate therapy. Consider non-hormonal options such as a copper IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Drospirenone with Felbamate?
MediHelp rates the interaction as moderate. Drospirenone and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can induce CYP3A4 and may reduce hormonal contraceptive concentrations, risking contraceptive failure. Reduced efficacy of drospirenone-containing products is therefore possible.
How serious is the interaction between Drospirenone and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative non-hormonal contraceptive method during felbamate therapy. Consider non-hormonal options such as a copper IUD.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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