Drug interactions
Duloxetine + Eliglustat
Severity: Major
Duloxetine and Eliglustat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and can increase eliglustat exposure, which prolongs PR, QRS, and QT intervals. The risk is greatest in patients who also receive CYP3A inhibitors or are poor CYP2D6 metabolizers.
What this interaction means in plain words
Duloxetine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Duloxetine inhibits CYP2D6, the main enzyme metabolizing eliglustat, raising its plasma concentrations.
What to do
Reduce eliglustat to 84 mg once daily in extensive and intermediate metabolizers and monitor ECG. Avoid the combination if a CYP3A inhibitor is also used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Duloxetine with Eliglustat?
MediHelp rates the interaction as major. Duloxetine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duloxetine is a moderate CYP2D6 inhibitor and can increase eliglustat exposure, which prolongs PR, QRS, and QT intervals. The risk is greatest in patients who also receive CYP3A inhibitors or are poor CYP2D6 metabolizers.
How serious is the interaction between Duloxetine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat to 84 mg once daily in extensive and intermediate metabolizers and monitor ECG. Avoid the combination if a CYP3A inhibitor is also used.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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