Drug interactions
Duloxetine + Elranatamab
Severity: Moderate
Duloxetine and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab causes cytokine release syndrome, and raised cytokines can transiently suppress CYP450 enzymes. Duloxetine is cleared mainly by CYP1A2 and CYP2D6, so its exposure may rise around step-up dosing and during CRS, increasing adverse effects such as nausea, dizziness or serotonergic toxicity.
What this interaction means in plain words
Duloxetine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP1A2 and other CYP enzymes during CRS reduces duloxetine metabolism.
What to do
Monitor for duloxetine adverse effects during step-up dosing and for up to 14 days after, and during any CRS episode. Reduce the duloxetine dose or hold it if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Duloxetine with Elranatamab?
MediHelp rates the interaction as moderate. Duloxetine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab causes cytokine release syndrome, and raised cytokines can transiently suppress CYP450 enzymes. Duloxetine is cleared mainly by CYP1A2 and CYP2D6, so its exposure may rise around step-up dosing and during CRS, increasing adverse effects such as nausea, dizziness or serotonergic toxicity.
How serious is the interaction between Duloxetine and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects during step-up dosing and for up to 14 days after, and during any CRS episode. Reduce the duloxetine dose or hold it if toxicity appears.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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