Drug interactions
Duloxetine + Eluxadoline
Severity: Minor
Duloxetine and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is mainly a substrate of CYP1A2 and CYP2D6 and is only a moderate CYP2D6 inhibitor, not a CYP1A2 inhibitor. It is not expected to raise eluxadoline exposure meaningfully, and eluxadoline is mainly cleared by other routes.
What this interaction means in plain words
Duloxetine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; duloxetine is not a strong CYP1A2 inhibitor.
What to do
No routine action is required beyond monitoring for eluxadoline adverse effects such as constipation or abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Duloxetine with Eluxadoline?
MediHelp rates the interaction as minor. Duloxetine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine is mainly a substrate of CYP1A2 and CYP2D6 and is only a moderate CYP2D6 inhibitor, not a CYP1A2 inhibitor. It is not expected to raise eluxadoline exposure meaningfully, and eluxadoline is mainly cleared by other routes.
How serious is the interaction between Duloxetine and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required beyond monitoring for eluxadoline adverse effects such as constipation or abdominal pain.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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