Drug interactions
Duloxetine + Ethacrynic acid
Severity: Moderate
Duloxetine and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid can cause hyponatremia and hypovolemia, and duloxetine can cause SIADH-related hyponatremia. The combination may increase hyponatremia risk, particularly in older adults.
What this interaction means in plain words
Duloxetine and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive effects on sodium balance from diuretic sodium loss and SIADH induced by duloxetine.
What to do
Monitor serum sodium after initiation and with dose changes, especially in older patients. Stop or adjust therapy if symptomatic hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Duloxetine with Ethacrynic acid?
MediHelp rates the interaction as moderate. Duloxetine and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid can cause hyponatremia and hypovolemia, and duloxetine can cause SIADH-related hyponatremia. The combination may increase hyponatremia risk, particularly in older adults.
How serious is the interaction between Duloxetine and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium after initiation and with dose changes, especially in older patients. Stop or adjust therapy if symptomatic hyponatremia develops.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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