Drug interactions
Duloxetine + Fluphenazine
Severity: Moderate
Duloxetine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is metabolized by CYP2D6, and duloxetine can raise its concentrations. This may increase extrapyramidal symptoms, sedation and other dose-related effects.
What this interaction means in plain words
Duloxetine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated fluphenazine metabolism by duloxetine.
What to do
Watch for parkinsonism, akathisia and excessive sedation after duloxetine is started or the dose is increased. Lower the fluphenazine dose if these effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Duloxetine with Fluphenazine?
MediHelp rates the interaction as moderate. Duloxetine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is metabolized by CYP2D6, and duloxetine can raise its concentrations. This may increase extrapyramidal symptoms, sedation and other dose-related effects.
How serious is the interaction between Duloxetine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for parkinsonism, akathisia and excessive sedation after duloxetine is started or the dose is increased. Lower the fluphenazine dose if these effects develop.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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