Drug interactions
Duloxetine + Furosemide
Severity: Moderate
Duloxetine and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum sodium, so combining them may increase the chance of hyponatremia. Older patients and those with low body weight are at highest risk, and symptoms include confusion, headache and falls.
What this interaction means in plain words
Duloxetine and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced sodium loss combined with SNRI-associated SIADH produces additive hyponatremia.
What to do
Check serum sodium at baseline and within the first weeks of combined therapy, particularly in the elderly. Stop or switch the serotonergic drug if clinically significant hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Furosemide?
MediHelp rates the interaction as moderate. Duloxetine and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum sodium, so combining them may increase the chance of hyponatremia. Older patients and those with low body weight are at highest risk, and symptoms include confusion, headache and falls.
How serious is the interaction between Duloxetine and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and within the first weeks of combined therapy, particularly in the elderly. Stop or switch the serotonergic drug if clinically significant hyponatremia develops.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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