Drug interactions
Duloxetine + Haloperidol
Severity: Moderate
Duloxetine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is partly metabolized by CYP2D6, and duloxetine inhibits this enzyme, which may increase haloperidol exposure. Haloperidol can also inhibit CYP2D6 and modestly raise duloxetine levels. Raised haloperidol exposure increases extrapyramidal and QT-related risks.
What this interaction means in plain words
Duloxetine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Mutual CYP2D6 inhibition, mainly reducing haloperidol clearance by duloxetine.
What to do
Monitor for extrapyramidal symptoms and sedation, and consider an ECG in patients with QT risk factors. Reduce the haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Duloxetine with Haloperidol?
MediHelp rates the interaction as moderate. Duloxetine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is partly metabolized by CYP2D6, and duloxetine inhibits this enzyme, which may increase haloperidol exposure. Haloperidol can also inhibit CYP2D6 and modestly raise duloxetine levels. Raised haloperidol exposure increases extrapyramidal and QT-related risks.
How serious is the interaction between Duloxetine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, and consider an ECG in patients with QT risk factors. Reduce the haloperidol dose if adverse effects appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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