Drug interactions
Duloxetine + Iloperidone
Severity: Moderate
Duloxetine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP2D6 and CYP3A4, and duloxetine moderately inhibits CYP2D6, which can raise iloperidone levels. Higher exposure may increase QT prolongation, sedation and orthostatic hypotension.
What this interaction means in plain words
Duloxetine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated iloperidone metabolism by duloxetine.
What to do
Monitor for QT effects, sedation and orthostasis. Labeling advises reducing the iloperidone dose by about half with strong CYP2D6 inhibitors, so consider a lower dose with duloxetine if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Duloxetine with Iloperidone?
MediHelp rates the interaction as moderate. Duloxetine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is metabolized by CYP2D6 and CYP3A4, and duloxetine moderately inhibits CYP2D6, which can raise iloperidone levels. Higher exposure may increase QT prolongation, sedation and orthostatic hypotension.
How serious is the interaction between Duloxetine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for QT effects, sedation and orthostasis. Labeling advises reducing the iloperidone dose by about half with strong CYP2D6 inhibitors, so consider a lower dose with duloxetine if adverse effects occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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