Drug interactions
Duloxetine + Lornoxicam
Severity: Moderate
Duloxetine and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs reduce platelet serotonin and NSAIDs such as lornoxicam injure gastric mucosa and inhibit platelet function. Together they increase the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Duloxetine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis: SNRI-induced platelet serotonin depletion plus NSAID COX inhibition and mucosal injury.
What to do
Use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or other bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Duloxetine with Lornoxicam?
MediHelp rates the interaction as moderate. Duloxetine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs reduce platelet serotonin and NSAIDs such as lornoxicam injure gastric mucosa and inhibit platelet function. Together they increase the risk of upper gastrointestinal bleeding.
How serious is the interaction between Duloxetine and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or other bleeding.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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