Drug interactions
Duloxetine + Lurasidone
Severity: Minor
Duloxetine and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system, and combined use may increase sedation, dizziness and orthostatic effects. Serotonergic antidepressants combined with antipsychotics can rarely contribute to serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Duloxetine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS and pharmacodynamic effects; no significant pharmacokinetic interaction is established.
What to do
The combination is commonly used; monitor for sedation, orthostasis and signs of serotonin toxicity after initiation or dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Duloxetine with Lurasidone?
MediHelp rates the interaction as minor. Duloxetine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the central nervous system, and combined use may increase sedation, dizziness and orthostatic effects. Serotonergic antidepressants combined with antipsychotics can rarely contribute to serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Duloxetine and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination is commonly used; monitor for sedation, orthostasis and signs of serotonin toxicity after initiation or dose changes.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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