Drug interactions
Duloxetine + Midazolam
Severity: Minor
Duloxetine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine may add to drowsiness and psychomotor impairment with midazolam. Significant respiratory depression is unlikely, and duloxetine is a moderate CYP2D6 inhibitor with little effect on midazolam.
What this interaction means in plain words
Duloxetine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Mild additive CNS effects; no significant pharmacokinetic interaction expected.
What to do
No dose change usually needed; monitor sedation after midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Midazolam?
MediHelp rates the interaction as minor. Duloxetine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine may add to drowsiness and psychomotor impairment with midazolam. Significant respiratory depression is unlikely, and duloxetine is a moderate CYP2D6 inhibitor with little effect on midazolam.
How serious is the interaction between Duloxetine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change usually needed; monitor sedation after midazolam.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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