Drug interactions
Duloxetine + Nabumetone
Severity: Moderate
Duloxetine and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine combined with nabumetone increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is higher in elderly patients, those with prior ulcers, and those on anticoagulants or corticosteroids.
What this interaction means in plain words
Duloxetine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Nabumetone belongs to Musculoskeletal.
Why it happens
Serotonin reuptake inhibition reduces platelet serotonin and aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in higher-risk patients. Advise patients to report black stools or other bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Nabumetone?
MediHelp rates the interaction as moderate. Duloxetine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine combined with nabumetone increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is higher in elderly patients, those with prior ulcers, and those on anticoagulants or corticosteroids.
How serious is the interaction between Duloxetine and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in higher-risk patients. Advise patients to report black stools or other bleeding.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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