Drug interactions
Duloxetine + Peginterferon alfa 2b
Severity: Minor
Duloxetine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter CYP2D6 (and CYP1A2) metabolism of duloxetine, with an uncertain direction. Clinical impact is probably small. Duloxetine is sometimes used for interferon-induced depression.
What this interaction means in plain words
Duloxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP1A2 and CYP2D6; not firmly established.
What to do
Monitor antidepressant response and adverse effects such as nausea, blood pressure rise and hepatic effects. Adjust the duloxetine dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Duloxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter CYP2D6 (and CYP1A2) metabolism of duloxetine, with an uncertain direction. Clinical impact is probably small. Duloxetine is sometimes used for interferon-induced depression.
How serious is the interaction between Duloxetine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and adverse effects such as nausea, blood pressure rise and hepatic effects. Adjust the duloxetine dose as needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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