Drug interactions
Duloxetine + Perphenazine
Severity: Moderate
Duloxetine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a CYP2D6 inhibitor and substrate, and duloxetine is a moderate CYP2D6 inhibitor, so each may raise the other's levels. This may increase sedation, extrapyramidal effects and QT effects, and duloxetine exposure may rise modestly.
What this interaction means in plain words
Duloxetine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Mutual CYP2D6 competition and inhibition, with additive CNS and serotonergic effects.
What to do
Monitor for extrapyramidal symptoms, sedation and duloxetine adverse effects. Consider reducing the perphenazine dose when duloxetine is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Duloxetine with Perphenazine?
MediHelp rates the interaction as moderate. Duloxetine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a CYP2D6 inhibitor and substrate, and duloxetine is a moderate CYP2D6 inhibitor, so each may raise the other's levels. This may increase sedation, extrapyramidal effects and QT effects, and duloxetine exposure may rise modestly.
How serious is the interaction between Duloxetine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and duloxetine adverse effects. Consider reducing the perphenazine dose when duloxetine is started.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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