Drug interactions
Duloxetine + Piroxicam
Severity: Moderate
Duloxetine and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, a serotonin-norepinephrine reuptake inhibitor, increases bleeding risk when combined with NSAIDs, particularly in the upper GI tract. The risk is highest in older patients or with a history of ulcers.
What this interaction means in plain words
Duloxetine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
Impaired platelet serotonin uptake by duloxetine adds to NSAID platelet inhibition and mucosal injury.
What to do
Consider a proton pump inhibitor in at-risk patients and use the lowest effective NSAID dose briefly. Monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Piroxicam?
MediHelp rates the interaction as moderate. Duloxetine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, increases bleeding risk when combined with NSAIDs, particularly in the upper GI tract. The risk is highest in older patients or with a history of ulcers.
How serious is the interaction between Duloxetine and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and use the lowest effective NSAID dose briefly. Monitor for GI bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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