Drug interactions
Duloxetine + Ritlecitinib
Severity: Moderate
Duloxetine and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2, the main enzyme clearing duloxetine, so duloxetine exposure may rise. This may increase nausea, dizziness, somnolence and blood pressure effects.
What this interaction means in plain words
Duloxetine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ritlecitinib belongs to Oncology.
Why it happens
Inhibition of CYP1A2-mediated duloxetine metabolism by ritlecitinib.
What to do
Monitor for duloxetine adverse effects and blood pressure, and reduce the duloxetine dose if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Duloxetine with Ritlecitinib?
MediHelp rates the interaction as moderate. Duloxetine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2, the main enzyme clearing duloxetine, so duloxetine exposure may rise. This may increase nausea, dizziness, somnolence and blood pressure effects.
How serious is the interaction between Duloxetine and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and blood pressure, and reduce the duloxetine dose if tolerability is poor.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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