Drug interactions
Duloxetine + Talquetamab
Severity: Moderate
Duloxetine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, and elevated cytokines can suppress CYP450 enzymes. This may transiently increase exposure to duloxetine, a CYP1A2 and CYP2D6 substrate, and raise the risk of adverse effects such as nausea, dizziness or serotonergic toxicity.
What this interaction means in plain words
Duloxetine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP1A2 activity reduces duloxetine clearance during and after cytokine release syndrome.
What to do
Monitor for duloxetine adverse effects during step-up dosing and for about two weeks after the first treatment dose and during any cytokine release syndrome. Reduce the duloxetine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Duloxetine with Talquetamab?
MediHelp rates the interaction as moderate. Duloxetine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, and elevated cytokines can suppress CYP450 enzymes. This may transiently increase exposure to duloxetine, a CYP1A2 and CYP2D6 substrate, and raise the risk of adverse effects such as nausea, dizziness or serotonergic toxicity.
How serious is the interaction between Duloxetine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects during step-up dosing and for about two weeks after the first treatment dose and during any cytokine release syndrome. Reduce the duloxetine dose if toxicity appears.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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