Drug interactions
Duloxetine + Tipranavir
Severity: Moderate
Duloxetine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is generally given with ritonavir, which inhibits CYP2D6 and CYP3A4 and may increase duloxetine concentrations. This may increase adverse effects such as nausea, dizziness and blood pressure elevation. Ritonavir can also induce CYP1A2, so the net effect is uncertain.
What this interaction means in plain words
Duloxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 by ritonavir-boosted tipranavir potentially raising duloxetine exposure, partly offset by CYP1A2 induction.
What to do
Start duloxetine at a low dose and titrate slowly while monitoring tolerability. Reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Duloxetine and Tipranavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Duloxetine with Tipranavir?
MediHelp rates the interaction as moderate. Duloxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is generally given with ritonavir, which inhibits CYP2D6 and CYP3A4 and may increase duloxetine concentrations. This may increase adverse effects such as nausea, dizziness and blood pressure elevation. Ritonavir can also induce CYP1A2, so the net effect is uncertain.
How serious is the interaction between Duloxetine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start duloxetine at a low dose and titrate slowly while monitoring tolerability. Reduce the dose if adverse effects emerge.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
