Drug interactions
Dupilumab + Sirolimus
Severity: Minor
Dupilumab and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab blocks IL-4/IL-13 signalling and may reverse cytokine-mediated suppression of CYP enzymes. This could change sirolimus exposure, a narrow therapeutic index drug, though no clinically significant effect has been established.
What this interaction means in plain words
Dupilumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dupilumab belongs to Respiratory; Sirolimus belongs to Miscellaneous.
Why it happens
Theoretical normalisation of cytokine-suppressed CYP3A4 expression as inflammation is controlled.
What to do
Check sirolimus trough levels after starting or stopping dupilumab if there is clinical concern, and adjust the dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Dupilumab
Frequently asked questions
Can I take Dupilumab with Sirolimus?
MediHelp rates the interaction as minor. Dupilumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dupilumab blocks IL-4/IL-13 signalling and may reverse cytokine-mediated suppression of CYP enzymes. This could change sirolimus exposure, a narrow therapeutic index drug, though no clinically significant effect has been established.
How serious is the interaction between Dupilumab and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough levels after starting or stopping dupilumab if there is clinical concern, and adjust the dose accordingly.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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