Drug interactions
Dupilumab + Tacrolimus
Severity: Minor
Dupilumab and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab may reverse cytokine-mediated suppression of CYP450 enzymes and thereby lower concentrations of sensitive substrates. For a narrow therapeutic index drug such as tacrolimus this could alter levels.
What this interaction means in plain words
Dupilumab and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dupilumab belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Normalization of cytokine-suppressed CYP450 expression as inflammation resolves.
What to do
Check tacrolimus trough levels after starting or stopping dupilumab and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Dupilumab
Frequently asked questions
Can I take Dupilumab with Tacrolimus?
MediHelp rates the interaction as minor. Dupilumab and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dupilumab may reverse cytokine-mediated suppression of CYP450 enzymes and thereby lower concentrations of sensitive substrates. For a narrow therapeutic index drug such as tacrolimus this could alter levels.
How serious is the interaction between Dupilumab and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or stopping dupilumab and adjust the dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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