Drug interactions
Dutasteride + Rifapentine
Severity: Minor
Dutasteride and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and may lower dutasteride exposure. Reduced dutasteride effect is possible during extended rifamycin therapy, though clinical consequences are not well documented.
What this interaction means in plain words
Dutasteride and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Rifapentine belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifapentine accelerates dutasteride metabolism.
What to do
No dose adjustment is routinely required; reassess urinary symptoms or PSA response if dutasteride seems less effective during rifapentine treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Dutasteride with Rifapentine?
MediHelp rates the interaction as minor. Dutasteride and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces CYP3A4 and may lower dutasteride exposure. Reduced dutasteride effect is possible during extended rifamycin therapy, though clinical consequences are not well documented.
How serious is the interaction between Dutasteride and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; reassess urinary symptoms or PSA response if dutasteride seems less effective during rifapentine treatment.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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