Drug interactions
Dutasteride + Verapamil
Severity: Minor
Dutasteride and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and has been shown to modestly raise dutasteride concentrations. Given dutasteride's wide therapeutic margin, this is rarely clinically important.
What this interaction means in plain words
Dutasteride and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing dutasteride clearance.
What to do
No dose adjustment is required; monitor for dutasteride adverse effects and for hypotension or bradycardia from verapamil as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Dutasteride with Verapamil?
MediHelp rates the interaction as minor. Dutasteride and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and has been shown to modestly raise dutasteride concentrations. Given dutasteride's wide therapeutic margin, this is rarely clinically important.
How serious is the interaction between Dutasteride and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for dutasteride adverse effects and for hypotension or bradycardia from verapamil as usual.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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