Drug interactions
Dutasteride-tamsulosin + Enzalutamide
Severity: Moderate
Dutasteride-tamsulosin and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower tamsulosin and dutasteride exposure. Reduced therapeutic effect on urinary symptoms is possible.
What this interaction means in plain words
Dutasteride-tamsulosin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases the metabolism of tamsulosin and dutasteride.
What to do
Monitor symptom control and consider alternative therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Enzalutamide?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may lower tamsulosin and dutasteride exposure. Reduced therapeutic effect on urinary symptoms is possible.
How serious is the interaction between Dutasteride-tamsulosin and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider alternative therapy if response is lost.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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