Drug interactions
Dutasteride-tamsulosin + Posaconazole
Severity: Major
Dutasteride-tamsulosin and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can increase tamsulosin and dutasteride exposure. Hypotension and syncope risk is increased.
What this interaction means in plain words
Dutasteride-tamsulosin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces clearance of tamsulosin and dutasteride.
What to do
Avoid concurrent use when possible, or withhold tamsulosin during posaconazole therapy. If both are used, monitor blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Posaconazole?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor and can increase tamsulosin and dutasteride exposure. Hypotension and syncope risk is increased.
How serious is the interaction between Dutasteride-tamsulosin and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible, or withhold tamsulosin during posaconazole therapy. If both are used, monitor blood pressure.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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