Drug interactions
Dutasteride-tamsulosin + Tucatinib
Severity: Moderate
Dutasteride-tamsulosin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can increase exposure to sensitive CYP3A substrates such as tamsulosin. Higher tamsulosin levels may lead to orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing the metabolic clearance of tamsulosin and dutasteride.
What to do
Monitor blood pressure and orthostatic symptoms, particularly during the first weeks of co-therapy. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Tucatinib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can increase exposure to sensitive CYP3A substrates such as tamsulosin. Higher tamsulosin levels may lead to orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly during the first weeks of co-therapy. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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