Drug interactions
Edoxaban + Fostamatinib
Severity: Moderate
Edoxaban and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-gp and may raise edoxaban concentrations. Fostamatinib can also cause thrombocytopenia-related bleeding concerns in some settings.
What this interaction means in plain words
Edoxaban and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein increases edoxaban absorption and reduces efflux.
What to do
Monitor for bleeding and platelet counts; consider reducing the edoxaban dose if bleeding signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Edoxaban with Fostamatinib?
MediHelp rates the interaction as moderate. Edoxaban and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits P-gp and may raise edoxaban concentrations. Fostamatinib can also cause thrombocytopenia-related bleeding concerns in some settings.
How serious is the interaction between Edoxaban and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet counts; consider reducing the edoxaban dose if bleeding signs appear.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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