Drug interactions
Edoxaban + Ranolazine
Severity: Moderate
Edoxaban and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and may raise edoxaban exposure, increasing bleeding risk. The effect is expected to be modest compared with strong P-gp inhibitors.
What this interaction means in plain words
Edoxaban and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by ranolazine reduces edoxaban efflux and clearance.
What to do
Monitor for bleeding signs, and consider edoxaban dose reduction where labeling advises for P-gp inhibitors, such as in VTE treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Ranolazine?
MediHelp rates the interaction as moderate. Edoxaban and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein and may raise edoxaban exposure, increasing bleeding risk. The effect is expected to be modest compared with strong P-gp inhibitors.
How serious is the interaction between Edoxaban and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs, and consider edoxaban dose reduction where labeling advises for P-gp inhibitors, such as in VTE treatment.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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