Drug interactions
Edoxaban + Stiripentol
Severity: Moderate
Edoxaban and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may inhibit P-glycoprotein, which limits the intestinal absorption and promotes the elimination of edoxaban. Exposure to edoxaban could therefore rise, increasing the risk of bleeding. The size of the effect is not well characterized.
What this interaction means in plain words
Edoxaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Possible inhibition of P-glycoprotein efflux transport by stiripentol, raising edoxaban exposure.
What to do
Monitor for bleeding signs and renal function when the combination is needed. Consider an alternative anticoagulant if bleeding occurs or risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Edoxaban with Stiripentol?
MediHelp rates the interaction as moderate. Edoxaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may inhibit P-glycoprotein, which limits the intestinal absorption and promotes the elimination of edoxaban. Exposure to edoxaban could therefore rise, increasing the risk of bleeding. The size of the effect is not well characterized.
How serious is the interaction between Edoxaban and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and renal function when the combination is needed. Consider an alternative anticoagulant if bleeding occurs or risk is high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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