Drug interactions
Efavirenz + Rolapitant
Severity: Moderate
Efavirenz and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and may lower rolapitant concentrations, particularly with chronic dosing. Reduced rolapitant effect could lead to poorer control of delayed nausea and vomiting.
What this interaction means in plain words
Efavirenz and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Efavirenz induces CYP3A4, increasing rolapitant clearance.
What to do
Consider an antiemetic alternative not reliant on rolapitant. If given, monitor for breakthrough nausea and vomiting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Rolapitant?
MediHelp rates the interaction as moderate. Efavirenz and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and may lower rolapitant concentrations, particularly with chronic dosing. Reduced rolapitant effect could lead to poorer control of delayed nausea and vomiting.
How serious is the interaction between Efavirenz and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antiemetic alternative not reliant on rolapitant. If given, monitor for breakthrough nausea and vomiting.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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