Drug interactions
Elacestrant + Posaconazole
Severity: Major
Elacestrant and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase elacestrant exposure, since it is mainly cleared by CYP3A4. This may increase adverse effects such as nausea, dyslipidemia and hepatic effects.
What this interaction means in plain words
Elacestrant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces elacestrant clearance.
What to do
Avoid concomitant use with strong CYP3A4 inhibitors per labeling and choose an alternative antifungal. If unavoidable, monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Posaconazole?
MediHelp rates the interaction as major. Elacestrant and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can increase elacestrant exposure, since it is mainly cleared by CYP3A4. This may increase adverse effects such as nausea, dyslipidemia and hepatic effects.
How serious is the interaction between Elacestrant and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with strong CYP3A4 inhibitors per labeling and choose an alternative antifungal. If unavoidable, monitor for adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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