Drug interactions
Elagolix + Lapatinib
Severity: Moderate
Elagolix and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may reduce lapatinib levels, though it can also inhibit P-glycoprotein and raise exposure of substrates. The net effect on lapatinib is uncertain.
What this interaction means in plain words
Elagolix and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Lapatinib belongs to Oncology.
Why it happens
Opposing effects of CYP3A4 induction and P-glycoprotein inhibition by elagolix.
What to do
Monitor clinical response and lapatinib adverse effects. Adjust the lapatinib dose based on tolerability and efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Lapatinib?
MediHelp rates the interaction as moderate. Elagolix and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak to moderate CYP3A4 inducer and may reduce lapatinib levels, though it can also inhibit P-glycoprotein and raise exposure of substrates. The net effect on lapatinib is uncertain.
How serious is the interaction between Elagolix and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and lapatinib adverse effects. Adjust the lapatinib dose based on tolerability and efficacy.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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