Drug interactions
Elagolix + Metaxalone
Severity: Minor
Elagolix and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may reduce concentrations of CYP3A substrates. Metaxalone exposure could fall modestly, with a possible loss of effect.
What this interaction means in plain words
Elagolix and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Elagolix induces CYP3A4, increasing metabolic clearance of metaxalone.
What to do
Monitor muscle relaxant efficacy during co-therapy. Increase the metaxalone dose only if clinically needed and within labeled limits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Metaxalone?
MediHelp rates the interaction as minor. Elagolix and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may reduce concentrations of CYP3A substrates. Metaxalone exposure could fall modestly, with a possible loss of effect.
How serious is the interaction between Elagolix and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor muscle relaxant efficacy during co-therapy. Increase the metaxalone dose only if clinically needed and within labeled limits.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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